Blame the Environment: Why Vaccines May Be Ineffective for Some People

AdipoRon may be benefit for atherosclerosis prevention

Atherosclerosis has serious role in coronary arteries disease,so it is important to establish effective strategies for prevention or even treatment of atherosclerosis. Adiponectin, as one of the most abundant adipokines, has insulin sensitivity, anti-inflammatory and anti-atherogenic properties. Disturbed adiponectin actions through its receptor, (AdipoR1 and AdipoR2) may be involved in atheros...

O-8: Some Variations of the TSSK2 Gene May be Associated with Impaired Spermatogenesis

Background: Tssk2, a member of the testis specific serine/threonine kinase (TSSK) family, is expressed predominantly in the testis and crucial for the formation and function of the sperm cells in mouse. Targeted deletion of Tssk1 and 2 in male chimeric mice caused infertility due to haploinsufficiency of the genes. Therefore it is reasonable to postulate that mutations in its human homologue TS...

Why Even Good Defenses May be Bad

Why negative meta-analyses may be false?

Results of meta-analyses are regarded as the highest level of evidence. A statistically non-significant effect size from a meta-analysis is typically considered true negative even in the presence of a statistically significant signal in individual studies, presumed to be false positive. Here we provide examples from neuroimaging, genetics and psychopharmacology of why meta-analyses may frequent...

Why Reasons May Not Be Causes

This paper considers Davidson’s (1963) arguments for construing reasons as causes and attempts to show that he has failed to provide positive reasons for introducing causation into his analysis of rationalizing explanation. I consider various ways of spelling out his intuition that something is missing from explanation if we consider only the justificatory relation between reasons and action, a...